Karl Haushalter
Professor of Chemistry and Biology
Jacobs Science Center, Room 1218
301 Platt Blvd.
Claremont, CA 91711
909.607.3928
Karl_Haushalter@hmc.edu
Education and professional experience
- B.A., Rice University
- PhD, Harvard University
- Visiting Lecturer, University of California, Irvine
- Postdoctoral Fellow, University of California, San Diego
Teaching
- Bio 182: Chemistry in Living Systems
- Bio 184: Methods in Biochemistry
- Bio 187: HIV-AIDS: Science, Society and Service
- Bio 189: Topics in Biochemistry and Molecular Biology
- Chem 21: General Chemistry
- Chem 25: General Chemistry Laboratory
- Chem 58: Carbon Compounds Laboratory
- Chem 105: Organic Chemistry
- Chem 111: Organic Chemistry Laboratory
Research Interests
Double strand breaks or chemically modified bases in DNA arise from exposure to ionizing radiation, environmental toxins, or mistakes during DNA replication. DNA repair enzymes scan the genome and fix DNA damage to maintain genomic integrity. Studying the details of DNA repair provides an entry point into understanding the molecular mechanisms of carcinogenesis, aging, and evolution. Students in the Haushalter lab utilize biochemical and genetic approaches to study enzymes in the homologous recombination repair pathway and the base excision repair pathway. In addition to these scientific pursuits, Prof. Haushalter is active in community efforts to combat the stigma associated with HIV-AIDS and support those living with HIV-AIDS through education and empowerment. The HIV-AIDS: Science, Society, and Service class taught by Prof. Haushalter is an integrative experience, service-learning course that addresses both the science of HIV and the ways that the HIV epidemic has impacted communities.
Recent Student Projects
Matthew Hoss (鈥�08) and Sara Hummel (鈥�06): 鈥淪equence Specificity of Human 8-Oxoguanine DNA Glycosylase”
Katie Mouzakis (鈥�07), Yan Pu (鈥�06), and Tiffany Wu (鈥�06): 鈥淒NA Repair Efficiency of Variants of Human 8-oxoguanine DNA Glycosylase 1 (hOGG1) Identified in Cancer Patients鈥�
Fang-Yuan Chang (鈥�07): 鈥淭rapping the hOGG1:nucleosomal DNA complex鈥�
Brianna Lyon-Robers (鈥�06): 鈥淚mproved methods for in vitro nucleosome reconstitution鈥�
Steven Petesch (鈥�05): 鈥淟ocation mechanism of adenine路8-oxoguanine mismatches by MutY adenine DNA glycosylase鈥�
Sarah Bundick (鈥�05) and Ryan Mashiyama (鈥�04): 鈥淭arget Location by the DNA Repair Enzyme SMUG1鈥�
Kit Rodolfa (鈥�04): 鈥淪ynthesis of large fragments of DNA incorporating site-specific base lesions鈥�
Alexis Kaushansky (鈥�04): 鈥淔illing in the black box between I-CreI induced DNA cleavage and double-strand break repair鈥�
Selected Publications
Gemmen, G. J., R. Sim, K. A. Haushalter, P. C. Ke, J. T. Kadonaga and D. E. Smith. 2005. . J. Mol. Biol. 351: 89-99.
Wibley, J. E. A., T. R. Waters, K. Haushalter, G. L. Verdine and L. H. Pearl. 2003. . Mol. Cell. 11(6): 1647-1659.
K. A. Haushalter and J. T. Kadonaga. 2003. . Nat. Rev. Mol. Cell Biol. 4(8): 613-620.
L. Chen, K. A. Haushalter, C. M. Lieber, and G. L. Verdine. 2002. . Chem. Biol. 9: 345-350.
H. Nilsen,听K. A. Haushalter, P. Robins, D. E. Barnes, G. L. Verdine and T. Lindahl. 2001. .听EMBO J.听20: 4278-4286.
K. A. Haushalter, P. T. Stukenberg, M. W. Kirschner and G. L. Verdine. 1999. . Curr. Biol. 9: 174-185.
K. A. Haushalter, J. Lau, and J. D. Roberts. 1996. .听J. Amer. Chem. Soc.听118: 8891-8896.